FORPRION - Projects

• Basic research on prion diseases
  • Erl 8 Metal Ion Induced Conformational Changes in Peptides: A Putative Mechanism for the Formation of Abnormal Prion Protein Isoforms
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  • LMU 10 Pathophysiological role of prion proteins at hippocampal excitatory synaptic terminals
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  • LMU 2 Cu(II)-binding of PrPC: Influence on Structure, Conformational Dynamics and Infectivity
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  • LMU 5 Analysis of Bovine and Human Prions in Cell Culture Systems for Diagnostic, Analytical and Therapeutic Purposes
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  • LMU 6 In Vivo Phosphorylation and Cellular Transport of Mutant and WT Prion Proteins in Living Neurons
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  • LMU 9 Phenotyping of Prion Diseases using GFP-PrP Chimeras in Transgenic Mice
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• Consumer protection
  • Erl 3 High Sensitive Immunassay for Detection of Central Nervous Tissue in Food
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  • LMU 19 a Occurrence and Stability of the BSE Agent in Foodstuff (primarily in Milk and Milk Products) and in the Environment
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  • LMU 20 Species specific detection of central nervous tissue or other TSE risk material in meat products
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  • TUM 12 Natural Isotope Ratio of Bioelements as an Indicator of the Origin of Animal Products and of Animal Protein in Ruminant Feed
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• Diagnosis of prion diseases
  • LMU 4 Development of BSE-nvCJD-Fast-Assays and Development of therapeutics for the treatment of nvCJD
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  • LMU 8 Development of a Diagnostic Test for Prion Diseases in Blood
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  • TUM 16 Development of specific rcombinant anti- PrPSc antibodies
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• Epidemiology and Veterinary medicine
  • Bay 1 Occurence of TSE in natural habitats: Transmission of prions through wild animals and farmed wild ruminants in Northern Bavaria
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  • LMU 13 Studies the genetic diversity of the porcine prion protein.
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  • LMU 17 TSE in fish
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  • LMU 19 Clinical and Epidemiological Investigations of BSE in Bavaria
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  • LMU 19 a Occurrence and Stability of the BSE Agent in Foodstuff (primarily in Milk and Milk Products) and in the Environment
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  • LMU 21 Investigation of Sporadically Occurring Spongiform Brain Lesions in Cattle
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• Genetics
  • Erl 2 BSE Genomics C
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  • LMU 15 BSE Genomics A
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  • LMU 22 Generation of PrPC deficient cattle
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  • TUM 9 BSE Genomics B
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• Pathogenesis of prion diseases
  • LMU 11 Function of Dendritic Cells (DC) in the Pathogenesis of Prion Disease
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  • TUM 7 The Role of Activated Retroviral Genes as Cofactors in Prion-induced Spongiform Encephalopathy: Studies with a Mouse Model for Pathogenesis and Therapy
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  • Wü 1 Pathogenesis of Prion Diseases I
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  • Wü 1 Pathogenesis of Prion Diseases II
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  • Wü 1 Pathogenesis of Prion Diseases III
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  • Wü 1 Pathogenesis of Prion Diseases IV
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• Therapy of prion diseases
  • Therapeutical potential of stimulating innate immunity in prion disease
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  • LMU 5 Analysis of Bovine and Human Prions in Cell Culture Systems for Diagnostic, Analytical and Therapeutic Purposes
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  • MPI 1 Mechanism and Prevention of Scrapie Prion Protein Formation
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