ForInter

BAVARIAN RESEARCH ASSOCIATION INTERACTION OF HUMAN BRAIN CELLS

Research Association ForInter

Publications

21/10/2020

In preparation

Flegel, N.*, Furlanetto, F.*, Alfonsetti, M., Bohl, B., Turan, S., Lie, D.C., Kuhlmann, T., Winkler, J., Falk, S.*, Wegner, M.*, Karow, M.* (2023) Establishment of a novel human organoid model system reveals requirement of TCF4 for oligodendroglial differentiation.  In preparation

Frank S*, Gabassi E*, Käseberg S, Bertin M, Pfeiffer D, Brennenstuhl H, Falk S*, Karow M*, Schweiger S*. (2023) Absence of the RING domain in MID1 results in severe patterning defects in the developing human brain. (Manuscript in revision in Life Science Alliance)

Käseberg S* Bertin M*, Menon R*, Gabassi E*, Todorov H*, Frank S, Brennenstuhl H, Lohrer   B,        Winter J,         Krummeich J, Winkler J, Winner B, Weis E, Hartwich D,   Diederich S, Luck K, Gerber S, Lunt P, Berninger B,   Falk S*, Schweiger S*,          Karow M*. Dynamic X-chromosomal reactivation enhances female brain   resilience. BioRxiv 2023.06.17.545424 (Manuscript in revision in Cell).

Kremp, M., Aberle, T., Bohl, B., Sock, E., Hillgärtner, S., Winkler, J. & Wegner, M. (2023) The histone demethylase PHF8 influences oligodendroglial development by regulating OLIG2 expression. (In preparation)

Krumm, Pozner, Zagha, Coras, Arnold, Brumberg, Tsaktanis, Scherpelz, Davis, Kaindl, Stolzer, Süß, J. Riemenschneider, Baets, Günther, Meyer, Jayadev, Rothhammer, Krach, Winkler, Winner, Regensburger (2023) Myeloid cell activation in SPG11-related hereditary spastic paraplegia (submitted)

Nikolova, M. T., Catellani, A., Hinke, J., Okamoto, R., Lin, H.-C., Kaindl, J., He, Z., Geirsdottir, L., Camp, J. G., Amit, I., Winner, B., Treutlein, B. Single-cell transcriptomic landscape of stem cell-derived microglia and their co-culture with neural organoids. (in         preparation, current version shared)

 

Wihan J, Battis K, Hoffmann A, Himmler M, Schubert DW, Xiang W, Kuhlmann T, Winkler J (2023) Alpha synuclein–mediated cytoskeletal dysfunction impairs myelinogenesis in   human oligodendrocytes. Nature communications. (submitted)

Zhisong, Dony, Fleck, Szałata, X. Li,Slišković, Lin, Santel, Sun, Organoid Biological Network, J. Gray Camp, Fabian J. Theis, Barbara Treutlein. An integrated transcriptomic cell atlas of human neural organoids. (in preparation, current version   shared)

Zoppi F, Lohrer B, Kruse K, Kinfe T, Schichor C, Imayoshi I, Berninger B, Karow M*, Falk S*. Counteracting cellular safeguarding mechanisms during direct lineage reprogramming into human induced neurons. (2023) (Manuscript in preparation).

 

2022

Akdas, E. Y., Turan, S., Guhathakurta, D., Ekici, A., Salar, S., Lie, D. C., Winner, B., & Fejtova, A. (2023). CRISPR/Cas9-mediated generation of hESC lines with homozygote and heterozygote p.R331W mutation in CTBP1 to model HADDTS syndrome. Stem Cell Res, 67, 103012. https://doi.org/10.1016/j.scr.2022.103012

Asadollahi, R., Delvendahl, I., Muff, R., Tan, G., Rodríguez, D. G., Turan, S., Russo, M., Oneda, B., Joset, P., Boonsawat, P., Masood, R., Mocera, M., Ivanovski, I., Baumer, A., Bachmann-Gagescu, R., Schlapbach, R., Rehrauer, H., Steindl, K., Begemann, A., Reis, A., Winkler, J., Winner, B., Müller, M., & Rauch, A. (2023). Pathogenic SCN2A variants cause early-stage dysfunction in patient-derived neurons. Hum Mol Genet, 32(13), 2192-2204. https://doi.org/10.1093/hmg/ddad048      

Battis, K., Xiang, W., & Winkler, J. (2023). The Bidirectional Interplay of α-Synuclein with Lipids in the Central Nervous System and Its Implications for the Pathogenesis of Parkinson's Disease. Int J Mol Sci, 24(17). https://doi.org/10.3390/ijms241713270

Braun, F. K., Rothhammer-Hampl, T., Lorenz, J., Pohl, S., Menevse, A. N., Vollmann-Zwerenz, A., Bumes, E., Büttner, M., Zoubaa, S., Proescholdt, M., Schmidt, N. O., Hau, P., Beckhove, P., Winner, B., & Riemenschneider, M. J. (2023). Scaffold-Based (Matrigel™) 3D Culture Technique of Glioblastoma Recovers a Patient-like Immunosuppressive Phenotype. Cells, 12(14). https://doi.org/10.3390/cells12141856

Fischer, D. S., Schaar, A. C., & Theis, F. J. (2023). Modeling intercellular communication in tissues using spatial graphs of cells. Nat Biotechnol, 41(3), 332-336. https://doi.org/10.1038/s41587-022-01467-z

Fleck, J. S., Jansen, S. M. J., Wollny, D., Zenk, F., Seimiya, M., Jain, A., Okamoto, R., Santel, M., He, Z., Camp, J. G., & Treutlein, B. (2023). Inferring and perturbing cell fate regulomes in human brain organoids. Nature, 621(7978), 365-372. https://doi.org/10.1038/s41586-022-05279-8    

Heumos, L., Schaar, A. C., Lance, C., Litinetskaya, A., Drost, F., Zappia, L., Lücken, M. D.,      Strobl, D. C.,             Henao, J., Curion, F., Schiller, H. B., & Theis, F. J. (2023). Best   practices for single-    cell analysis across modalities. Nat           Rev Genet, 24(8), 550-          572. https://doi.org/10.1038/s41576023-00586-w 

Krach, F., Boerstler, T., Reischl, S., Krumm, L., Regensburger, M., Winkler, J., Winner, B.       (2023). RNA splicing modulator induces peripheral neuropathy with increased neurofilament light chain levels         via p53 signaling. bioRxiv 2023.08.02.551640;         doi: https://doi.org/10.1101/2023.08.02.551640

Marxreiter, F., Lambrecht, V., Mennecke, A., Hanspach, J., Jukic, J., Regensburger, M., Herrler, J., German, A., Kassubek, J., Grön, G., Müller, H. P., Laun, F. B., Dörfler, A., Winkler, J., & Schmidt, M. A. (2023). Parkinson's disease or multiple system atrophy: potential separation by quantitative susceptibility mapping. Ther Adv Neurol Disord, 16, 17562864221143834. https://doi.org/10.1177/17562864221143834           

Masanetz, R. K., Baum, W., Schett, G., Winkler, J., & Süß, P. (2023). Cellular plasticity and myeloid inflammation in the adult brain are independent of the transcriptional modulator DREAM. Neurosci Lett, 796, 137061. https://doi.org/10.1016/j.neulet.2023.137061

Menon, R., Petrucci, L., Lohrer, B., Zhang, J., Schulze, M., Schichor, C., Winner, B., Winkler, J., Riemenschneider, M. J., Kühn, R., Falk, S., & Karow, M. (2023). Human Induced Pluripotent Stem Cell-Derived Pericytes as Scalable and Editable Source to Study Direct Lineage Reprogramming Into Induced Neurons. Cell Reprogram. https://doi.org/10.1089/cell.2023.0008

Michielsen, L., Lotfollahi, M., Strobl D., Sikkema L., Reinders, M. J. T., Theis, F. J., Mahfouz, A. (2023). Single-cell reference mapping to construct and extend cell-type hierarchies. NAR Genomics and Bioinformatics, 5(3), lqad070. https://doi.org/10.1093/nargab/lqad070 

Rich-Griffin, C.,  Curion, F., Thomas, T., Agarwal, D., Theis F. J., (2023)  Dendrou, C. A., Panpipes: a pipeline for multiomic single-cell data analysis, bioRxiv. https://doi.org/10.1101/2023.03.11.532085

Sikkema, L., Ramírez-Suástegui, C., Strobl, D. C.., M. D., Theis, F. J., & Lung Biological Network, C. (2023). An integrated cell atlas of the lung in health and disease. Nature Medicine, 29(6), 1563-1577. https://doi.org/10.1038/s41591-023-02327-2

 

2022

Battis, K., Florio, J. B., Mante, M., Lana, A., Naumann, I., Gauer, C., Lambrecht, V., Müller, S. J., Cobo, I., Fixsen, B., Kim, H. Y., Masliah, E., Glass, C. K., Schlachetzki, J. C. M., Rissman, R. A., Winkler, J., & Hoffmann, A. (2022). CSF1R-Mediated Myeloid Cell Depletion Prolongs Lifespan But Aggravates Distinct Motor Symptoms in a Model of Multiple System Atrophy. J Neurosci, 42(40), 7673-7688. https://doi.org/10.1523/jneurosci.0417-22.2022

Dederer, H.-G., Hamburger, D. (2022). Are genome-edited micro-organisms covered by Directive 2009/41/EC?—implications of the CJEU’s judgment in the case C-528/16 for the contained use of genome-edited micro-organisms. Journal of Law and the Biosciences, 9 (2022), 1-27. https://doi.org/10.1093/jlb/lsab033

Gunther, C., Winner, B., Neurath, M. F., & Stappenbeck, T. S. (2022). Organoids in gastrointestinal diseases: from experimental models to clinical translation. Gut, 71(9), 1892-1908. https://doi.org/10.1136/gutjnl-2021-326560

Hrovatin, K., Bastidas-Ponce, A.,  Bakhti, M.,  Zappia, L., Büttner, M., Sallino, C., Sterr, M., Böttcher, A., Migliorini, A.,  Lickert, H.,  Theis, F. J. (2022) Delineating mouse β-cell identity during lifetime and in diabetes with a single cell atlas. bioRxiv.  https://doi.org/10.1101/2022.12.22.521557

Karpf, J., Unichenko, P., Chalmers, N., Beyer, F., Wittmann, M. T., Schneider, J., Fidan, E., Reis, A., Beckervordersandforth, J., Brandner, S., Liebner, S., Falk, S., Sagner, A., Henneberger, C., & Beckervordersandforth, R. (2022). Dentate gyrus astrocytes exhibit layer-specific molecular, morphological and physiological features. Nat Neurosci, 25(12), 1626-1638. https://doi.org/10.1038/s41593-022-01192-5          

Krach, F., Stemick, J., Boerstler, T., Weiss, A., Lingos, I., Reischl, S., Meixner, H., Ploetz, S., Farrell, M., Hehr, U., Kohl, Z., Winner, B., & Winkler, J. (2022). An alternative splicing modulator decreases mutant HTT and improves the molecular fingerprint in Huntington's disease patient neurons. Nat Commun, 13(1), 6797. https://doi.org/10.1038/s41467-022-34419-x

Krach, F., Wheeler, E. C., Regensburger, M., Boerstler, T., Wend, H., Vu, A. Q., Wang, R., Reischl, S., Boldt, K., Batra, R., Aigner, S., Ravits, J., Winkler, J., Yeo, G. W., & Winner, B. (2022). Aberrant NOVA1 function disrupts alternative splicing in early stages of amyotrophic lateral sclerosis. Acta Neuropathol, 144(3), 413-435. https://doi.org/10.1007/s00401-022-02450-3       

Lanfer, J., Kaindl, J., Krumm, L., Gonzalez Acera, M., Neurath, M., Regensburger, M., Krach, F., & Winner, B. (2022). Efficient and Easy Conversion of Human iPSCs into Functional Induced Microglia-like Cells. Int J Mol Sci, 23(9). https://doi.org/10.3390/ijms23094526

Luecken, M. D., Buttner, M., Chaichoompu, K., Danese, A., Interlandi, M., Mueller, M. F., Strobl, D. C., Zappia, L., Dugas, M., Colome-Tatche, M., & Theis, F. J. (2022). Benchmarking atlas-level data integration in single-cell genomics. Nat Methods, 19(1), 41-50. https://doi.org/10.1038/s41592-021-01336-8

Masanetz, R. K., Winkler, J., Winner, B., Günther, C., & Süß, P. (2022). The Gut-Immune-Brain Axis: An Important Route for Neuropsychiatric Morbidity in Inflammatory Bowel Disease. Int J Mol Sci, 23(19). https://doi.org/10.3390/ijms231911111

Palla, G., Spitzer, H., Klein, M., Fischer, D., Schaar, A. C., Kuemmerle, L. B., Rybakov, S., Ibarra, I. L., Holmberg, O., Virshup, I., Lotfollahi, M., Richter, S., & Theis, F. J. (2022). Squidpy: a scalable framework for spatial omics analysis. Nature Methods, 19(2), 171-178. https://doi.org/10.1038/s41592-021-01358-2 

Pieger, K., Schmitt, V., Gauer, C., Giessl, N., Prots, I., Winner, B., Winkler, J., Brandstatter, J. H., & Xiang, W. (2022). Translocation of Distinct Alpha Synuclein Species from the Nucleus to Neuronal Processes during Neuronal Differentiation. Biomolecules, 12(8). https://doi.org/10.3390/biom12081108

Prieto Huarcaya, S., Drobny, A., Marques, A. R. A., Di Spiezio, A., Dobert, J. P., Balta, D., Werner, C., Rizo, T., Gallwitz, L., Bub, S., Stojkovska, I., Belur, N. R., Fogh, J., Mazzulli, J. R., Xiang, W., Fulzele, A., Dejung, M., Sauer, M., Winner, B., Rose-John, S., Arnold, P., Saftig, P., & Zunke, F. (2022). Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models. Autophagy, 18(5), 1127-1151. https://doi.org/10.1080/15548627.2022.2045534            

Rizo, T., Gebhardt, L., Riedlberger, J., Eberhardt, E., Fester, L., Alansary, D., Winkler, J., Turan, S., Arnold, P., Niemeyer, B. A., Fischer, M. J. M., & Winner, B. (2022). Store-operated calcium entry is reduced in spastin-linked hereditary spastic paraplegia. Brain, 145(9), 3131-3146. https://doi.org/10.1093/brain/awac122

Schmidt, S., Luecken, M. D., Trümbach, D., Hembach, S., Niedermeier, K. M., Wenck, N., Pflügler, K., Stautner, C., Böttcher, A., Lickert, H., Ramirez-Suastegui, C., Ahmad, R., Ziller, M. J., Fitzgerald, J. C., Ruf, V., van de Berg, W. D. J., Jonker, A. J., Gasser, T., Winner, B., Winkler, J., Vogt Weisenhorn, D. M., Giesert, F., Theis, F. J., & Wurst, W. (2022). Primary cilia and SHH signaling impairments in human and mouse models of Parkinson's disease. Nat Commun, 13(1), 4819. https://doi.org/10.1038/s41467-022-32229-9  

Schneider, Y., Turan, S., Koller, A., Krumbiegel, M., Farrell, M., Plötz, S., Winkler, J., & Xiang, W. (2022). Generation of a homozygous and a heterozygous SNCA gene knockout human-induced pluripotent stem cell line by CRISPR/Cas9 mediated allele-specific tuning of SNCA expression. Stem Cell Res, 65, 102952. https://doi.org/10.1016/j.scr.2022.102952

Seebauer, L., Schneider, Y., Drobny, A., Plotz, S., Koudelka, T., Tholey, A., Prots, I., Winner, B., Zunke, F., Winkler, J., & Xiang, W. (2022). Interaction of Alpha Synuclein and Microtubule Organization Is Linked to Impaired Neuritic Integrity in Parkinson's Patient-Derived Neuronal Cells. Int J Mol Sci, 23(3). https://doi.org/10.3390/ijms23031812

Stern, S., Lau, S., Manole, A., Rosh, I., Percia, M. M., Ben Ezer, R., Shokhirev, M. N., Qiu, F., Schafer, S., Mansour, A. A., Mangan, K. P., Stern, T., Ofer, P., Stern, Y., Diniz Mendes, A. P., Djamus, J., Moore, L. R., Nayak, R., Laufer, S. H., Aicher, A., Rhee, A., Wong, T. L., Nguyen, T., Linker, S. B., Winner, B., Freitas, B. C., Jones, E., Sagi, I., Bardy, C., Brice, A., Winkler, J., Marchetto, M. C., & Gage, F. H. (2022). Reduced synaptic activity and dysregulated extracellular matrix pathways in midbrain neurons from Parkinson's disease patients. NPJ Parkinsons Dis, 8(1), 103. https://doi.org/10.1038/s41531-022-00366-z          

Triebelhorn, J., Cardon, I., Kuffner, K., Bader, S., Jahner, T., Meindl, K., Rothhammer-Hampl, T., Riemenschneider, M. J., Drexler, K., Berneburg, M., Nothdurfter, C., Manook, A., Brochhausen, C., Baghai, T. C., Hilbert, S., Rupprecht, R., Milenkovic, V. M., & Wetzel, C. H. (2022). Induced neural progenitor cells and iPS-neurons from major depressive disorder patients show altered bioenergetics and electrophysiological properties. Mol Psychiatry. https://doi.org/10.1038/s41380-022-01660-1        

van den Hurk, M., Lau, S., Marchetto, M. C., Mertens, J., Stern, S., Corti, O., Brice, A., Winner, B., Winkler, J., Gage, F. H., & Bardy, C. (2022). Druggable transcriptomic pathways revealed in Parkinson's patient-derived midbrain neurons. NPJ Parkinsons Dis, 8(1), 134. https://doi.org/10.1038/s41531-022-00400-0

Wolff, H. (2022). Patentierbarkeit von aus iPSZ hergestellten Gehirnorganoiden. GRUR, 124 (2022). 1473-1481.

Wolff, H., Pecikiewicz, J. (2022). Enhancement mit Gehirnorganoiden – Ethische und Rechtliche Probleme einer terra nova). MedR, 40 (2022), 907-917. https://doi.org/10.1007/s00350-022-6333-4

 

 

2021

Büttner, M., Ostner, J., Müller, C. L., Theis, F. J., & Schubert, B. (2021). scCODA is a Bayesian model for compositional single-cell data analysis. Nature Communications, 12(1), 6876. https://doi.org/10.1038/s41467-021-27150-6          

Dederer, H.-G., Hamburger, D., editors (2021). Brain Organoids in Research and Therapy. Emerging Ethical and Legal Issues. Springer.

Falk, S., Han, D., & Karow, M. (2021). Cellular identity through the lens of direct lineage reprogramming. Curr Opin Genet Dev, 70, 97-103. https://doi.org/10.1016/j.gde.2021.06.015

Fischer, D. S., Dony, L., König, M., Moeed, A., Zappia, L., Heumos, L., Tritschler, S., Holmberg, O., Aliee, H., & Theis, F. J. (2021). Sfaira accelerates data and model reuse in single cell genomics. Genome Biol, 22(1), 248. https://doi.org/10.1186/s13059-021-02452-6

Guner, F., Pozner, T., Krach, F., Prots, I., Loskarn, S., Schlotzer-Schrehardt, U., Winkler, J., Winner, B., & Regensburger, M. (2021). Axon-Specific Mitochondrial Pathology in SPG11 Alpha Motor Neurons. Front Neurosci, 15, 680572. https://doi.org/10.3389/fnins.2021.680572

Gunther, C., Rothhammer, V., Karow, M., Neurath, M., & Winner, B. (2021). The Gut-Brain Axis in Inflammatory Bowel Disease-Current and Future Perspectives. Int J Mol Sci, 22(16). https://doi.org/10.3390/ijms22168870

Krumm, L., Pozner, T., Kaindl, J., Regensburger, M., Gunther, C., Turan, S., Asadollahi, R., Rauch, A., & Winner, B. (2021). Generation and characterization of an endogenously tagged SPG11-human iPSC line by CRISPR/Cas9 mediated knock-in. Stem Cell Res, 56, 102520. https://doi.org/10.1016/j.scr.2021.102520

Mészáros, L., Riemenschneider, M. J., Gassner, H., Marxreiter, F., von Hörsten, S., Hoffmann, A., & Winkler, J. (2021). Human alpha-synuclein overexpressing MBP29 mice mimic functional and structural hallmarks of the cerebellar subtype of multiple system atrophy. Acta Neuropathol Commun, 9(1), 68. https://doi.org/10.1186/s40478-021-01166-x           

Rothhammer-Hampl, T., Liesenberg, F., Hansen, N., Hoja, S., Delic, S., Reifenberger, G., & Riemenschneider, M. J. (2021). Frequent Epigenetic Inactivation of DIRAS-1 and DIRAS-2 Contributes to Chemo-Resistance in Gliomas. Cancers (Basel), 13(20). https://doi.org/10.3390/cancers13205113

Wittmann, M.T., Katada, S., Sock, E., Kirchner, P., Ekici, A.B., Wegner, M., Nakashima, K., Lie, D.C. & Reis, A. (2021). scRNA sequencing uncovers a TCF4-dependent transcription factor network regulating commissure development in mouse. Development  Jul 15;148(14):dev196022. doi: 10.1242/dev.196022

Wolff, H., Kunz, A. (2021). Hirnorganoide – Ethische Herausforderungen und ihre Berücksichtigung und Umsetzung im Recht). MedR, 39 (2021), 800-808. https://doi.org/10.1007/s00350-021-5977-9

Zappia, L., & Theis, F. J. (2021). Over 1000 tools reveal trends in the single-cell RNA-seq analysis landscape. Genome Biol, 22(1), 301. https://doi.org/10.1186/s13059-021-02519-4

Zunke, F., Winner, B., Richter, F., & Caraveo, G. (2021). Editorial: Intracellular Mechanisms of α-Synuclein Processing. Front Cell Dev Biol, 9, 752378. https://doi.org/10.3389/fcell.2021.752378

 

2020

Boerstler, T., Wend, H., Krumbiegel, M., Kavyanifar, A., Reis, A., Lie, D. C., Winner, B., & Turan, S. (2020). CRISPR/Cas9 mediated generation of human ARID1B heterozygous knockout hESC lines to model Coffin-Siris syndrome. Stem Cell Res, 47, 101889. https://doi.org/10.3389/fcell.2021.752378

Krach, F., Bogiongko, M. E., & Winner, B. (2020). Decoding Parkinson's disease - iPSC-derived models in the OMICs era. Mol Cell Neurosci, 106, 103501. https://doi.org/10.1016/j.mcn.2020.103501

Kunz, A., Wolff, H. (2020). Hirnorganoide – Ethische Herausforderungen und ihre          Berücksichtigung und Umsetzung im Recht).

Lambrecht, V., Hanspach, J., Hoffmann, A., Seyler, L., Mennecke, A., Straub, S., Marxreiter, F., Bäuerle, T., Laun, F. B., & Winkler, J. (2020). Quantitative susceptibility mapping depicts severe myelin deficit and iron deposition in a transgenic model of multiple system atrophy. Exp Neurol, 329, 113314. https://doi.org/10.1016/j.expneurol.2020.113314

Lampert, A., Bennett, D. L., McDermott, L. A., Neureiter, A., Eberhardt, E., Winner, B., & Zenke, M. (2020). Human sensory neurons derived from pluripotent stem cells for disease modelling and personalized medicine. Neurobiol Pain, 8, 100055. https://doi.org/10.1016/j.ynpai.2020.100055

Lorenz, J., Rothhammer-Hampl, T., Zoubaa, S., Bumes, E., Pukrop, T., Kolbl, O., Corbacioglu, S., Schmidt, N. O., Proescholdt, M., Hau, P., & Riemenschneider, M. J. (2020). A comprehensive DNA panel next generation sequencing approach supporting diagnostics and therapy prediction in neurooncology. Acta Neuropathol Commun, 8(1), 124. https://doi.org/10.1186/s40478-020-01000-w

Pecikiewicz, J., Wolff, H. (2020). Enhancement mit Gehirnorganoiden – Ethische und Rechtliche Probleme einer terra incognita

Pozner, T., Regensburger, M., Engelhorn, T., Winkler, J., & Winner, B. (2020). Janus-faced spatacsin (SPG11): involvement in neurodevelopment and multisystem neurodegeneration. Brain, 143(8), 2369-2379. https://doi.org/10.1093/brain/awaa099

Regensburger, M., Stemick, J., Masliah, E., Kohl, Z., & Winner, B. (2020). Intracellular A53T Mutant α-Synuclein Impairs Adult Hippocampal Newborn Neuron Integration. Front Cell Dev Biol, 8, 561963. https://doi.org/10.3389/fcell.2020.561963

Simmnacher K, Krach F, Schneider Y, Alecu JE, Mautner L, Klein P, Roybon L, Prots I, Xiang W, Winner B. (2020) Unique signatures of stress-induced senescent human astrocytes. Exp Neurol.; 334:113466. doi: https://doi.org/10.3389/fncel.2019.00571

Stemick, J., Gauer, C., Wihan, J., Moceri, S., Xiang, W., von Hörsten, S., Kohl, Z., & Winkler, J. (2020). Compensatory neuritogenesis of serotonergic afferents within the striatum of a transgenic rat model of Parkinson's disease. Brain Res, 1748, 147119. https://doi.org/10.1016/j.brainres.2020.147119  

Wedel, M., Fröb, F., Elsesser, O., Wittmann, M. T., Lie, D. C., Reis, A., & Wegner, M. (2020). Transcription factor Tcf4 is the preferred heterodimerization partner for Olig2 in oligodendrocytes and required for differentiation. Nucleic Acids Res, 48(9), 4839-4857. https://doi.org/10.1093/nar/gkaa218         

 

2019

Alieva, M., Leidgens, V., Riemenschneider, M. J., Klein, C. A., Hau, P., & van Rheenen, J. (2019). Intravital imaging of glioma border morphology reveals distinctive cellular dynamics and contribution to tumor cell invasion. Sci Rep, 9(1), 2054. https://doi.org/10.1038/s41598-019-38625-4

Kaindl, J., & Winner, B. (2019). Disease Modeling of Neuropsychiatric Brain Disorders Using Human Stem Cell-Based Neural Models. Current topics in behavioral neurosciences, 42, 159–183. https://doi.org/10.1007/7854_2019_111

Maroni, M., Korner, J., Schuttler, J., Winner, B., Lampert, A., & Eberhardt, E. (2019). beta1 and beta3 subunits amplify mechanosensitivity of the cardiac voltage-gated sodium channel Nav1.5. Pflugers Arch, 471(11-12), 1481-1492. https://doi.org/10.1007/s00424-019-02324-w

Simmnacher, K., Lanfer, J., Rizo, T., Kaindl, J., & Winner, B. (2019). Modeling Cell-Cell Interactions in Parkinson's Disease Using Human Stem Cell-Based Models. Front Cell Neurosci, 13, 571. https://doi.org/10.3389/fncel.2019.00571

Turan, S., Boerstler, T., Kavyanifar, A., Loskarn, S., Reis, A., Winner, B., & Lie, D. C. (2019). A novel human stem cell model for Coffin-Siris syndrome-like syndrome reveals the importance of SOX11 dosage for neuronal differentiation and survival. Hum Mol Genet, 28(15), 2589-2599. https://doi.org/10.1093/hmg/ddz089

Information

Launching date

03.2019

End

02.2023