FORIMMUN

RESEARCH NETWORK FOR NEW STRATEGIES IN IMMUNOTHERAPY

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T3 - Immuntherapy of tumors by specific tissue ablation

Field of work:

Tumor Vaccine

Issues of future research:
The standard approach for immunotherapy of tumors is to target the immunsystem against specific tumor antigens. However, the expression of tumor specific antigens varies within a given tumor and between different partients. In this project, the use of antigens derived from the normal tissue from which the tumor originates will be evaluated as a possible target. This approach might be useful for the elimination of tumors in non-essential tissues, including breast- and prostate carcinoma. As a therapeutic, recombinant attenuated bacteria will be used.

Application:

If the experiments proof that this strategy is feasible and if suitable target antigens can be identified, a therapeutic vaccine can be developed and in the long run a prophylactic vaccine for high risk groups can be considered. The further clinical development will be performed by TheraImmune. TheraImmune is a recently founded company located in Würzburg, Germany, devoted to the development of novel tumor therapies based on live bacterial carriers.

Information

Launching date

09.2002

End

03.2006

Funded by

Bayerische Forschungsstiftung