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Coordination
Coordination Responsibilites and role of the coordination office The coordination office represents the network to the outside and is therefore the point of contact for all project partners and…
Reconstructing microglia interactions in 3D brain organoids using single-cell genomics
Reconstructing microglia interactions in 3D brain organoids using single-cell genomics Microglia regulate diverse aspects of brain homeostasis during development and disease, including cell death…
Identification of transcriptional networks controlling development of interhemispheric neuronal connections
Identification of transcriptional networks controlling development of interhemispheric neuronal connections Interaction of neurons in different brain regions is paramount for behavior, learning, and…
Central project
Central project The central project is the core project and will generate the basis for the integration of neuroscientific, bioinformatic and ethical as well as legal aspects into the consortium.…
Computational identification of ligand-receptor binding in single cell RNA-seq and application to neuron-microglia interaction
Computational identification of ligand-receptor binding in single cell RNA-seq and application to neuron-microglia interaction Experimental breakthroughs in single cell biology now enable…
Neuron-oligodendrocyte interaction: glial pathology in neurodegeneration
Neuron-oligodendrocyte interaction: glial pathology in neurodegeneration The generation of myelin sheaths is a crucial requirement for fast nerve conduction velocity in which the development of…
Dissecting the functional heterogeneity of human brain pericytes and their cellular interactions by employing 2D culture models and 3D organoid systems
Dissecting the functional heterogeneity of human brain pericytes and their cellular interactions by employing 2D culture models and 3D organoid systems Pericytes are endothelial-associated cells…
Legal and ethical issues concerning research on, and application of, brain cells derived from genome edited IPSCs
Legal and ethical issues concerning research on, and application of, brain cells derived from genome edited IPSCs Objectives: (1) Comprehensive analysis of the legal framework for current and…
3D human cell culture system for the investigation of gliomas
3D human cell culture system for the investigation of gliomas Conventional cell culture bears limitations to model glioma as it fails to retain the cellular heterogeneity of the parental tumors.…
Neuron-microglia interaction: physiological and pathological signatures
Neuron-microglia interaction: physiological and pathological signatures Microglia are multifunctional glial cells in the central nervous system (CNS) parenchyma. They provide an important link…